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While L-arginine was popular for its quick effects, it suffered from poor bioavailability due to rapid conversion by the arginase enzyme

A significant presence of a GSTP1-1 allelic variant (the GSTP1*C allelic variant) was found in late-onset AD patients 52

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The study demonstrated that polyphyllin I can effectively inhibit the phosphorylation of STAT3 in a concentration-dependent manner in a mouse model with gastric cancer [99]

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